Article
Lamivudine monotherapy and lamivudine plus interferon alpha combination therapy in HBeAg negative chronic hepatitis B not responding to previous interferon alpha monotherapy.
Acta gastro-enterologica Belgica - 1 Jan 2000
Akyuz Filiz, Kaymakoglu Sabahattin, Demir Kadir, Aksoy Nevzat, Karaca Cetin, Danalioglu Ahmet, Onel Derya, Badur Selim, Besisik Fatih, Cakaloglu Yilmaz, Okten Atilla
Abstract excerpt
BACKGROUND AND STUDY AIMS: To investigate the efficacy of the combined therapy of lamivudine (LAM) plus alpha interferon (IFN) and LAM monotherapy in HBeAg negative chronic hepatitis B (CHB) patients who were unresponsive to previous IFN monotherapy, and the incidence of YMDD mutations. PATIENTS-METHODS: Forty-five HBeAg negative patients were enrolled in this study. 24 of these were treated with LAM (100 mg/day,...
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