Article
Expression of SMARCB1 modulates steroid sensitivity in human lymphoblastoid cells: identification of a promoter SNP that alters PARP1 binding and SMARCB1 expression.
Human molecular genetics - 1 Oct 2007
Pottier Nicolas, Cheok Meyling H, Yang Wenjian, Assem Mahfoud, Tracey Lorraine, Obenauer John C, Panetta John C, Relling Mary V, Evans William E
Abstract excerpt
Although cure rate of childhood acute lymphoblastic leukemia (ALL) has surpassed 80%, drug resistance remains a major cause of treatment failure. We previously identified a panel of 33 genes differentially expressed in prednisolone sensitive versus resistant ALL cells from newly diagnosed children. Here we used bioinformatics to identify resistance genes most likely to contain single nucleotide polymorphisms...
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