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Physiologically achievable concentrations of genistein enhance telomerase activity in prostate cancer cells via the activation of STAT3

5 Jul 2007

Abstract excerpt

Telomerase contributes to the infinite replicative potential of cancer cells by conferring proliferation and survival through the regulation of growth factors and apoptotic proteins. Although it is generally known that the phytoestrogen, genistein, has telomerase-repressing and anti-proliferative effects on various cancer cells at pharmacological concentrations, we report here that physiologically achievable...

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PMID: 17615260
DOI: 10.1093/carcin/bgm148

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