Article
Cancer genes associated with phenotypes in monoallelic and biallelic mutation carriers: new lessons from old players.
Human molecular genetics - 15 Apr 2007
Rahman Nazneen, Scott Richard H
Abstract excerpt
Autosomal dominant cancer predisposition genes for common cancers such as breast cancer and colorectal cancer have been well recognized for over a decade. Monoallelic mutations in these genes are associated with high risks of adult-onset cancer. In recent years, it has become apparent that biallelic mutations in some of these genes, such as BRCA2, MSH2 and MLH1, result in distinctive phenotypes, including...
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