Article
Structure-function relationships in a bacterial DING protein.
FEBS letters - 24 Jul 2007
Ahn Soyeon, Moniot Sebastien, Elias Mikael, Chabriere Eric, Kim Donghyo, Scott Ken
Abstract excerpt
A recombinant DING protein from Pseudomonas fluorescens has been previously shown to have a phosphate-binding site, and to be mitogenic for human cells. Here we report the three-dimensional structure of the protein, confirming a close similarity to the "Venus flytrap" structure seen in other human and bacterial phosphate-binding proteins. Site-directed mutagenesis confirms the role of a key residue involved in...
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