Article
Trisomy 19 is associated with trisomy 12 and mutated IGHV genes in B-chronic lymphocytic leukaemia.
British journal of haematology - 1 Jul 2007
Sellmann Ludger, Gesk Stefan, Walter Christoph, Ritgen Matthias, Harder Lana, Martín-Subero José I, Schroers Roland, Siemer Dörte, Nückel Holger, Dyer Martin J S, Dührsen Ulrich, Siebert Reiner, Dürig Jan, Küppers Ralf
Abstract excerpt
The occurrence of trisomy 19 was investigated in 705 cases of B-chronic lymphocytic leukaemia (CLL) by metaphase cytogenetic and/or fluorescence in situ hybridisation analyses. Trisomy 19 was detected in 11 cases (1.6%), all of which also carried a trisomy 12; nine of 10 had mutated IGHV genes. In contrast, B-CLL cases with trisomy 12 lacking trisomy 19 mostly had unmutated IGHV genes. Karyotypes of the present...
Topics
- Chromosomes, Human, Pair 12
- Chromosomes, Human, Pair 19
- Cluster Analysis
- Female
- Genes, Neoplasm
- Humans
- Immunoglobulin Heavy Chains
- Immunoglobulin Variable Region
- Leukemia, Lymphocytic, Chronic, B-Cell
- Male
- Middle Aged
- Mutation