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Gene Expression Analysis of Photoreceptor Cell Loss in<i>Bbs4</i>-Knockout Mice Reveals an Early Stress Gene Response and Photoreceptor Cell Damage

25 Jun 2007

Abstract excerpt

PURPOSE: To identify and characterize gene expression changes associated with photoreceptor cell loss in a Bbs4-knockout mouse model of retinal degeneration. METHODS: Differential gene expression in the eyes of 5-month-old Bbs4(-/-) mice undergoing retinal degeneration were analyzed using gene microarrays (Affymetrix, Santa Clara, CA). Elevated ocular transcripts were confirmed by Northern blotting of RNA from...

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PMID: 17591906
DOI: 10.1167/iovs.06-1477

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