Article
High sodium intake strengthens the association of ACE I/D polymorphism with blood pressure in a community.
American journal of hypertension - 1 Jul 2007
Yamagishi Kazumasa, Tanigawa Takeshi, Cui Renzhe, Tabata Minako, Ikeda Ai, Yao Masayuki, Shimamoto Takashi, Iso Hiroyasu
Abstract excerpt
BACKGROUND: Limited evidence is available on a gene-environment interaction of angiotensin-converting enzyme (ACE) gene I/D polymorphism and high blood pressure (BP) with salt intake among general populations. We hypothesized that persons with the I allele of the ACE gene have elevated BP levels in response to a higher sodium intake, and thus the association of ACE I/D polymorphism with BP levels was stronger...
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