SalY of theStreptococcus pyogenesLantibiotic Locus Is Required for Full Virulence and Intracellular Survival in Macrophages

Abstract excerpt

Streptococcus pyogenes utilizes numerous mechanisms for evading the host immune response but has only recently been found to survive in the intracellular environment. In this study, we demonstrate the requirement of a putative ABC transporter permease for intracellular survival in macrophages. The highly attenuated S. pyogenes mutant, SalY, was identified from a transposon mutagenesis screen, with over 200-fold...