Article
Reducing irinotecan-associated diarrhea in children.
Pediatric blood & cancer - 1 Feb 2008
Wagner Lars M, Crews Kristine R, Stewart Clinton F, Rodriguez-Galindo Carlos, McNall-Knapp Rene Y, Albritton Karen, Pappo Alberto S, Furman Wayne L
Abstract excerpt
Irinotecan is increasingly being used in pediatric oncology. Amelioration of diarrhea associated with protracted irinotecan administration may reduce morbidity and improve dose intensity. In this review, we discuss what is known about the pathogenesis of this toxicity as well as potential predisp...
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