Article
The low VEGF production allele of the +936C/T polymorphism is strongly associated with increased risk for oral cancer.
Journal of cancer research and clinical oncology - 1 Oct 2007
Yapijakis C, Vairaktaris E, Vassiliou S, Vylliotis A, Nkenke E, Nixon A M, Derka S, Spyridonidou S, Vorris E, Neukam F, Patsouris E
Abstract excerpt
PURPOSE: Based on the well-established role of vascular endothelial growth factor (VEGF) in tumor-associated angiogenesis in several cancer types and its undefined role in oral oncogenesis, we investigated the possible association of an expression-regulating polymorphism (+936C/T) with risk for oral squamous cell carcinoma (OSCC). METHODS: We studied the allele frequencies of the +936C/T polymorphism in DNA...
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