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Article

The low VEGF production allele of the +936C/T polymorphism is strongly associated with increased risk for oral cancer.

Journal of cancer research and clinical oncology - 1 Oct 2007

Yapijakis C, Vairaktaris E, Vassiliou S, Vylliotis A, Nkenke E, Nixon A M, Derka S, Spyridonidou S, Vorris E, Neukam F, Patsouris E

Abstract excerpt

PURPOSE: Based on the well-established role of vascular endothelial growth factor (VEGF) in tumor-associated angiogenesis in several cancer types and its undefined role in oral oncogenesis, we investigated the possible association of an expression-regulating polymorphism (+936C/T) with risk for oral squamous cell carcinoma (OSCC). METHODS: We studied the allele frequencies of the +936C/T polymorphism in DNA...

Topics

Adult
Aged
Aged, 80 and over
Alleles
Carcinoma, Squamous Cell
Female
Genetic Predisposition to Disease
Genotype
Humans
Male
Middle Aged

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mouth Neoplasms

Polymerase Chain Reaction

Polymorphism, Restriction Fragment Length

Vascular Endothelial Growth Factor A

Source

Identifiers

PMID: 17564725
DOI: 10.1007/s00432-007-0240-y

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-17564725-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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