Article
Impaired processing of FLP and NLP peptides in carboxypeptidase E (EGL-21)-deficient Caenorhabditis elegans as analyzed by mass spectrometry.
Journal of neurochemistry - 1 Jul 2007
Husson Steven J, Janssen Tom, Baggerman Geert, Bogert Brigitte, Kahn-Kirby Amanda H, Ashrafi Kaveh, Schoofs Liliane
Abstract excerpt
Biologically active peptides are synthesized from inactive pre-proproteins or peptide precursors by the sequential actions of processing enzymes. Proprotein convertases cleave the precursor at pairs of basic amino acids, which are then removed from the carboxyl terminus of the generated fragments...
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