Article
Genotyping of Pneumocystis jiroveci pneumonia in Italian AIDS patients. Clinical outcome is influenced by dihydropteroate synthase and not by internal transcribed spacer genotype.
Journal of acquired immune deficiency syndromes (1999) - 15 Aug 2007
Valerio Antonella, Tronconi Elisa, Mazza Francesca, Fantoni Giovanna, Atzori Chiara, Tartarone Federica, Duca Piergiorgio, Cargnel Antonietta
Abstract excerpt
BACKGROUND: Two Pneumocystis jiroveci independent genomic regions, internal transcribed spacer (ITS) 1 and ITS2, and dihydropteroate synthase (DHPS) gene have been used for typing a cohort of HIV-infected Italian patients with P jiroveci pneumonia (PcP). METHODS: Bronchoalveolar lavage samples isolated from 207 HIV-infected adults were ITS and DHPS genotyped by DNA sequencing and by restriction fragment length...
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