Article
Genetic polymorphisms in the amino acid transporters LAT1 and LAT2 in relation to the pharmacokinetics and side effects of melphalan.
Pharmacogenetics and genomics - 1 Jul 2007
Kühne Annett, Kaiser Rolf, Schirmer Markus, Heider Ulrike, Muhlke Sabine, Niere Wiebke, Overbeck Tobias, Hohloch Karin, Trümper Lorenz, Sezer Orhan, Brockmöller Jürgen
Abstract excerpt
OBJECTIVES: Melphalan is widely used in the treatment of multiple myeloma. Pharmacokinetics of this alkylating drug shows high inter-individual variability. As melphalan is a phenylalanine derivative, the pharmacokinetic variability may be determined by genetic polymorphisms in the L-type amino acid transporters LAT1 (SLC7A5) and LAT2 (SLC7A8). METHODS: Pharmacokinetics were analysed in 64 patients after first...
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