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Article

Genetic polymorphisms in the amino acid transporters LAT1 and LAT2 in relation to the pharmacokinetics and side effects of melphalan.

Pharmacogenetics and genomics - 1 Jul 2007

Kühne Annett, Kaiser Rolf, Schirmer Markus, Heider Ulrike, Muhlke Sabine, Niere Wiebke, Overbeck Tobias, Hohloch Karin, Trümper Lorenz, Sezer Orhan, Brockmöller Jürgen

Abstract excerpt

OBJECTIVES: Melphalan is widely used in the treatment of multiple myeloma. Pharmacokinetics of this alkylating drug shows high inter-individual variability. As melphalan is a phenylalanine derivative, the pharmacokinetic variability may be determined by genetic polymorphisms in the L-type amino a...

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Share to Amino Acid Substitution
Share to Antineoplastic Agents, Alkylating

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Lymphoma, Non-Hodgkin

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Share to Multiple Myeloma

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Source

Identifiers

PMID: 17558306
DOI: 10.1097/FPC.0b013e3280ea77cd

Genes

LAT2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-17558306-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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