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Article

Herpes simplex virus VP22 enhances adenovirus-mediated microdystrophin gene transfer to skeletal muscles in dystrophin-deficient (mdx) mice.

Human gene therapy - 1 Jun 2007

Xiong Fu, Xiao Shaobo, Peng Funing, Zheng Hui, Yu Meijuan, Ruan Yechun, Li Wanyi, Shang Yanchang, Zhao Cuiping, Zhou Wenliang, Chen Huanchun, Chamberlain Jeffrey S, Fang Liurong, Zhang Cheng

Abstract excerpt

One of the obstacles to efficient vector-mediated gene therapy for Duchenne's muscular dystrophy (DMD) is its limited transduction efficiency. The VP22 tegument protein of herpes simplex virus type 1 (HSV-1) is able to cross biological membranes and translocate the VP22 fusion protein from transf...

Read the complete abstract on PubMed

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Share to Adenoviridae
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Dystrophin

Share to Mice, Inbred mdx

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Share to Muscle Fibers, Skeletal

Share to Muscular Dystrophy, Animal

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Source

Identifiers

PMID: 17550336
DOI: 10.1089/hum.2006.155

Genes

DMD

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-17550336-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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