Article
Detection of genomic copy number changes in patients with idiopathic mental retardation by high-resolution X-array-CGH: important role for increased gene dosage of XLMR genes.
Human mutation - 1 Oct 2007
Froyen Guy, Van Esch Hilde, Bauters Marijke, Hollanders Karen, Frints Suzanna G M, Vermeesch Joris R, Devriendt Koen, Fryns Jean-Pierre, Marynen Peter
Abstract excerpt
A tiling X-chromosome-specific genomic array with a theoretical resolution of 80 kb was developed to screen patients with idiopathic mental retardation (MR) for submicroscopic copy number differences. Four patients with aberrations previously detected at lower resolution were first analyzed. This facilitated delineation of the location and extent of the aberration at high resolution and subsequently, more precise...
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