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Fetal Growth and Intrauterine Epigenetic Programming of Obesity and Cardiometabolic Disease

1 Jun 2022

Abstract excerpt

Epidemiologic studies have shown an association between an adverse intrauterine environment (eg, exposure to malnutrition) and an increased risk of developing cardiometabolic disease in adulthood. These studies laid the foundation for the developmental origins of health and disease hypothesis, which states that limited nutrient supply to the fetus results in physiologic and metabolic adaptations that favor...

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PMID: 35641462
DOI: 10.1542/neo.23-6-e363

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