Article
Analysis of mismatched DNA by mismatch binding ligand (MBL)-Sepharose affinity chromatography.
Analytical and bioanalytical chemistry - 1 Jul 2007
Goto Yuki, Suda Hitoshi, Kobori Akio, Nakatani Kazuhiko
Abstract excerpt
Mismatch binding molecules (MBLs), strongly and selectively bound to the mismatched base pair in duplex DNA, were immobilized on Sepharose. Three MBL-Sepharose columns were prepared with three MBLs, naphthyridine dimer (ND), naphthyridine-azaquinolone (NA), and aminonaphthyridine dimer (amND), which exhibited different binding profiles to the mismatched base pairs. These three MBL-Sepharose columns showed...
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