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Article

Farnesyl transferase inhibitor resistance probed by target mutagenesis.

Blood - 15 Sept 2007

Raz Tal, Nardi Valentina, Azam Mohammad, Cortes Jorge, Daley George Q

Abstract excerpt

Mutation in the target oncoprotein is a common mechanism of resistance to tyrosine kinase inhibitors, as exemplified by the many BCR/ABL mutations that thwart imatinib activity in patients with chronic myelogenous leukemia. It remains unclear whether normal cellular protein targets of chemotherap...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Leukemia, Myelogenous, Chronic, BCR-ABL Positive

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Source

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Identifiers

PMID: 17536018
DOI: 10.1182/blood-2006-12-064907
PMCID: PMC1976354

Genes

BCR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-17536018-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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