Article
Tumor suppressor p16INK4a--modulator of glycomic profile and galectin-1 expression to increase susceptibility to carbohydrate-dependent induction of anoikis in pancreatic carcinoma cells.
The FEBS journal - 1 Jul 2007
André Sabine, Sanchez-Ruderisch Hugo, Nakagawa Hiroaki, Buchholz Malte, Kopitz Jürgen, Forberich Pia, Kemmner Wolfgang, Böck Corina, Deguchi Kisaburo, Detjen Katharia M, Wiedenmann Bertram, von Knebel Doeberitz Magnus, Gress Thomas M, Nishimura Shin-Ichiro, Rosewicz Stefan, Gabius Hans-Joachim
Abstract excerpt
Expression of the tumor suppressor p16(INK4a) after stable transfection can restore the susceptibility of epithelial tumor cells to anoikis. This property is linked to increases in the expression and cell-surface presence of the fibronectin receptor. Considering its glycan chains as pivotal signa...
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