Article
Estimating the rate of accumulating drug resistance mutations in the HIV genome.
Value in health : the journal of the International Society for Pharmacoeconomics and Outcomes Research - 1 Jan 2000
Braithwaite R Scott, Shechter Steven, Chang Chung-Chou H, Schaefer Andrew, Roberts Mark S
Abstract excerpt
OBJECTIVE: HIV mutation accumulation has great implications for pharmacoeconomics and clinical care, yet scarcity of data has hindered its representation in decision analytic models. Our objective is to determine the accuracy with which mutation accumulation and other unmeasured parameters could be estimated during model calibration. METHODS: We used a second-order Monte Carlo simulation of HIV natural history...
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