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Gene Expression Analyses of Subchondral Bone in Early Experimental Osteoarthritis by Microarray

27 Feb 2012

Abstract excerpt

Osteoarthritis (OA) is a degenerative joint disease that affects both cartilage and bone. A better understanding of the early molecular changes in subchondral bone may help elucidate the pathogenesis of OA. We used microarray technology to investigate the time course of molecular changes in the subchondral bone in the early stages of experimental osteoarthritis in a rat model. We identified 2,234 differentially...

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PMID: 22384228
DOI: 10.1371/journal.pone.0032356

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