Article
Large-scale gene expression profiling reveals major pathogenetic pathways of cartilage degeneration in osteoarthritis.
Arthritis and rheumatism - 1 Nov 2006
Aigner Thomas, Fundel Katrin, Saas Joachim, Gebhard Pia M, Haag Jochen, Weiss Tilo, Zien Alexander, Obermayr Franz, Zimmer Ralf, Bartnik Eckart
Abstract excerpt
OBJECTIVE: Despite many research efforts in recent decades, the major pathogenetic mechanisms of osteoarthritis (OA), including gene alterations occurring during OA cartilage degeneration, are poorly understood, and there is no disease-modifying treatment approach. The present study was therefore initiated in order to identify differentially expressed disease-related genes and potential therapeutic targets....
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