Article
Microbial and dietary factors associated with the 8-prenylnaringenin producer phenotype: a dietary intervention trial with fifty healthy post-menopausal Caucasian women.
The British journal of nutrition - 1 Nov 2007
Bolca Selin, Possemiers Sam, Maervoet Veerle, Huybrechts Inge, Heyerick Arne, Vervarcke Stefaan, Depypere Herman, De Keukeleire Denis, Bracke Marc, De Henauw Stefaan, Verstraete Willy, Van de Wiele Tom
Abstract excerpt
Hop-derived food supplements and beers contain the prenylflavonoids xanthohumol (X), isoxanthohumol (IX) and the very potent phyto-oestrogen (plant-derived oestrogen mimic) 8-prenylnaringenin (8-PN). The weakly oestrogenic IX can be bioactivated via O-demethylation to 8-PN. Since IX usually predominates over 8-PN, human subjects may be exposed to increased doses of 8-PN. A dietary intervention trial with fifty...
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