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Tissue-Engineered Follicles Produce Live, Fertile Offspring

1 Oct 2006

Abstract excerpt

Oocytes grown in vitro are of low quality and yield few live births, thus limiting the ability to store or bank the ova of women wishing to preserve their fertility. We applied tissue engineering principles to the culture of immature mouse follicles by designing an alginate hydrogel matrix to maintain the oocyte's 3- dimensional (3D) architecture and cell-cell interactions in vitro. A 3D culture mimics the in...

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Identifiers

PMID: 17518643
DOI: 10.1089/ten.2006.12.2739

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