Article
Freeze-drying of live attenuated Vibrio anguillarum mutant for vaccine preparation.
Biologicals : journal of the International Association of Biological Standardization - 1 Oct 2007
Yang Lu, Ma Yue, Zhang Yuanxing
Abstract excerpt
Vibrio anguillarum MVAV6203 is a mutant strain as a candidate of live attenuated vaccine. In vaccine preparation, the freeze-drying conditions of the strain were investigated to improve the survival after freeze-drying, including the protectant, rehydration medium, freezing temperature, and initial cell concentration. Vibrio anguillarum MVAV6203 is sensitive to freeze-drying and the viability was only 0.03% in...
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