Article
Interaction between CYP1A2-T2467DELT polymorphism and smoking in adenocarcinoma and squamous cell carcinoma of the lung.
Lung cancer (Amsterdam, Netherlands) - 1 Sept 2007
Pavanello Sofia, B'chir Fatma, Pulliero Alessandra, Saguem Saâd, Ben Fraj Radhia, El Aziz Hayouni Abed, Clonfero Erminio, Mastrangelo Giuseppe
Abstract excerpt
This study aimed to identify new genetic characteristics contributing to individual susceptibility to smoke-induced lung cancer. Despite functional evidence of a possible role of cytochrome P450 1A2 (CYP1A2) in lung cancer susceptibility, no studies have evaluated the influence of CYP1A2 genotypes on lung cancer risk. We investigated the interaction between CYP1A2-T2467delT (allele*1D) polymorphism and smoking in...
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