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Article

The effect of ABCG2 V12M, Q141K and Q126X, known functional variants in vitro, on the disposition of lamivudine.

British journal of clinical pharmacology - 1 Nov 2007

Kim Ho-Sook, Sunwoo Yu Eun, Ryu Ji Young, Kang Ho-Jin, Jung Hye-Eun, Song Im-Sook, Kim Eun-Young, Shim Joo-Cheol, Shon Ji-Hong, Shin Jae-Gook

Abstract excerpt

AIMS: To evaluate the effects of three ABCG2 variants (Q141K, V12M and Q126X), which are known to have altered transport properties in vitro, on the disposition of lamivudine in healthy subjects. METHODS: To evaluate whether lamivudine is a substrate of ABCG2, intracellular accumulation and vectorial transport of 3H-lamivudine were determined in MDCK-ABCG2 cells. The pharmacokinetic parameters of lamivudine were...

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Share to ATP Binding Cassette Transporter, Subfamily G, Member 2
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Dose-Response Relationship, Drug

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Share to Polymorphism, Single Nucleotide

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Source

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Identifiers

PMID: 17509035
DOI: 10.1111/j.1365-2125.2007.02944.x
PMCID: PMC2203270

Genes

ABCG2

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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