Article
Mutation in CEP290 discovered for cat model of human retinal degeneration.
The Journal of heredity - 1 Jan 2000
Menotti-Raymond Marilyn, David Victor A, Schäffer Alejandro A, Stephens Robert, Wells David, Kumar-Singh Rajendra, O'Brien Stephen J, Narfström Kristina
Abstract excerpt
A mutation in the CEP290 gene is reported in a cat pedigree segregating for autosomal recessive (AR) late-onset photoreceptor degeneration (rdAc). An initial screen of 39 candidate genes and genomic locations failed to detect linkage to cat rdAc. Linkage was ultimately established on cat B4 with 15 simple tandem repeat markers (logarithm of odds [LOD] range 4.83-15.53, Theta = 0.0), in a region demonstrating...
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