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Article

Prospective assessment of XPD Lys751Gln and XRCC1 Arg399Gln single nucleotide polymorphisms in lung cancer.

Clinical cancer research : an official journal of the American Association for Cancer Research - 15 May 2007

Giachino Daniela F, Ghio Paolo, Regazzoni Silvia, Mandrile Giorgia, Novello Silvia, Selvaggi Giovanni, Gregori Dario, DeMarchi Mario, Scagliotti Giorgio V

Abstract excerpt

PURPOSE: XRCC1 and XPD play key roles in the repair of DNA lesions and adducts. Contrasting findings have been reported on the effect of polymorphisms of these genes on the response to platinum-based chemotherapy in advanced non-small-cell lung cancer (NSCLC). This study aimed to investigate the relationship between the XPD Lys751Gln and XRCC1 Arg399Gln genotypes and outcome in lung cancer patients. EXPERIMENTAL...

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Source

Identifiers

PMID: 17504986
DOI: 10.1158/1078-0432.CCR-06-2543

Genes

XRCC1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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