Article
Mechanical load initiates hypertrophic scar formation through decreased cellular apoptosis.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 1 Oct 2007
Aarabi Shahram, Bhatt Kirit A, Shi Yubin, Paterno Josemaria, Chang Edward I, Loh Shang A, Holmes Jeffrey W, Longaker Michael T, Yee Herman, Gurtner Geoffrey C
Abstract excerpt
Hypertrophic scars occur following cutaneous wounding and result in severe functional and esthetic defects. The pathophysiology of this process remains unknown. Here, we demonstrate for the first time that mechanical stress applied to a healing wound is sufficient to produce hypertrophic scars in mice. The resulting scars are histopathologically identical to human hypertrophic scars and persist for more than six...
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