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Article

Absence of nucleophosmin 1 (NPM1) gene mutations in common solid cancers.

APMIS : acta pathologica, microbiologica, et immunologica Scandinavica - 1 Apr 2007

Jeong Eun Goo, Lee Sung Hak, Yoo Nam Jin, Lee Sug Hyung

Abstract excerpt

Nucleophosmin is a nucleolar phosphoprotein that shuttles between nucleus and cytoplasm. Recent reports demonstrated that exon 12 of the nucleophosmin 1 (NPM1) gene was frequently mutated in acute myelogenous leukemias (AMLs). To see whether the NPM1 mutation occurs in other malignancies, we analyzed exon 12 of NPM1 for the detection of somatic mutations in 467 carcinomas, including 142 lung, 47 hepatocellular,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 17504301
DOI: 10.1111/j.1600-0463.2007.apm_592.x

Genes

NPM1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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