Article
Molecular classification and genetic pathways in hyperplastic polyposis syndrome.
The Journal of pathology - 1 Aug 2007
Carvajal-Carmona L G, Howarth K M, Lockett M, Polanco-Echeverry G M, Volikos E, Gorman M, Barclay E, Martin L, Jones A M, Saunders B, Guenther T, Donaldson A, Paterson J, Frayling I, Novelli M R, Phillips R, Thomas H J W, Silver A, Atkin W, Tomlinson I P M
Abstract excerpt
Hyperplastic Polyposis (HPPS) is a poorly characterized syndrome that increases colorectal cancer (CRC) risk. We aimed to provide a molecular classification of HPPS. We obtained 282 tumours from 32 putative HPPS patients with >or= 10 hyperplastic polyps (HPs); some patients also had adenomas and CRCs. We found no good evidence of microsatellite instability (MSI) in our samples. The epithelium of HPs was...
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