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Article

Activation of the lectin DC-SIGN induces an immature dendritic cell phenotype triggering Rho-GTPase activity required for HIV-1 replication.

Nature immunology - 1 Jun 2007

Hodges Ashleigh, Sharrocks Katherine, Edelmann Mariola, Baban Dilair, Moris Arnaud, Schwartz Olivier, Drakesmith Hal, Davies Kay, Kessler Benedikt, McMichael Andrew, Simmons Alison

Abstract excerpt

DC-SIGN, a C-type lectin expressed on dendritic cells (DCs), can sequester human immunodeficiency virus (HIV) virions in multivesicular bodies. Here, using large-scale gene expression profiling and tyrosine-phosphorylated proteome analyses, we characterized signaling mediated by DC-SIGN after activation by either HIV or a DC-SIGN-specific antibody. Activation of DC-SIGN resulted in downregulation of genes...

Read the complete abstract on PubMed

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Share to Cell Adhesion Molecules
Share to Dendritic Cells

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Guanine Nucleotide Exchange Factors

Share to Lectins, C-Type

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Share to Receptors, Cell Surface

Share to rho GTP-Binding Proteins

Share to Rho Guanine Nucleotide Exchange Factors

Source

Identifiers

PMID: 17496896
DOI: 10.1038/ni1470

Genes

ATF3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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