Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Cathepsin D deficiency and NCL/Batten disease: there's more to death than apoptosis.

Autophagy - 1 Jan 2000

Shacka John J, Roth Kevin A

Abstract excerpt

Animal models of cathepsin D (CD) deficiency are characterized by a progressive and relentless neurodegenerative phenotype similar to that observed in Neuronal Ceroid Lipofuscinoses (NCL), a group of pediatric neurodegenerative diseases known collectively as Batten Disease. We have shown recently that the targeted deletion of the pro-apoptotic molecule Bax prevents apoptotic markers but not neuron death and...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Apoptosis
Share to Autophagy
Share to Cathepsin D

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to NCL gene

Share to Mutation

Share to Nerve Degeneration

Share to Neuronal Ceroid-Lipofuscinoses

Share to Neurons

Source

Identifiers

PMID: 17495518
DOI: 10.4161/auto.4341

Genes

NCL

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Cathepsin D deficiency and NCL/Batten disease: there's more to death than apoptosis.PMID 17495518Read ↗

Batten disease: clinical aspects, molecular mechanisms, translational science, and future directions.Semantic proximity Read ↗

Selectivity and Types of Cell Death in the Neuronal Ceroid Lipofuscinoses (NCLs)Semantic proximity Read ↗

The neuronal ceroid-lipofuscinoses.Semantic proximity Read ↗

Lack of Cathepsin D in the Central Nervous System Results in Microglia and Astrocyte Activation and the Accumulation of Proteinopathy-related ProteinsSemantic proximity Read ↗

Autophagy in the Neuronal Ceroid Lipofuscinoses (Batten Disease)Semantic proximity Read ↗

NCL disease mechanisms.Semantic proximity Read ↗

Neurodegenerative disease: the neuronal ceroid lipofuscinoses (Batten disease).Semantic proximity Read ↗

Progress towards understanding the neurobiology of Batten disease or neuronal ceroid lipofuscinosisSemantic proximity Read ↗

Progress towards understanding the neurobiology of Batten disease or neuronal ceroid lipofuscinosis.Semantic proximity Read ↗

Batten disease: four genes and still counting.Semantic proximity Read ↗

Altered protein secretion in Batten disease.Semantic proximity Read ↗

Comparative biology of the neuronal ceroid-lipofuscinoses (NCL): an overview.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.