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Neurotrophin activation of NFAT‐dependent transcription contributes to the regulation of pro‐nociceptive genes

27 Jul 2007

Abstract excerpt

Nerve growth factor (NGF) and brain-derived neurotrophic factor (BDNF) play key roles in the development of inflammation-induced hyperalgesia by triggering the expression of pro-nociceptive genes within primary afferent and spinal neurons. However, the mechanisms by which neurotrophins elicit gene expression remain largely unknown. Recently, neurotrophins have been shown to activate members of the calcineurin...

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PMID: 17488277
DOI: 10.1111/j.1471-4159.2007.04632.x

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