Article
A review of cis-trans interplay between DNA sequences 5' to the (G)gamma- and beta-globin genes among Hb F-Malta-I heterozygotes/homozygotes and beta-thalassemia homozygotes/compound heterozygotes, and the effects of hydroxyurea on the Hb F/F-erythrocyte; the need for large multicenter trials.
Hemoglobin - 1 Jan 2007
Felice Alex E, Borg Joseph, Pizzuto Monica, Cassar Wilhelmina, Galdies Ruth, Wettinger Stephanie Bezzina, Pulis Svetlana, Hunter Gary J, Caruana Mary R, Farrugia Mario, Scerri Christian A
Abstract excerpt
The biosynthesis of Hb F in place of the deficient Hb A could be a suitable treatment for beta hemoglobinopathies. Among newborn Hb F-Malta-I heterozygotes, it could be shown that the XmnI sequence alone had little, if any effect on gamma-globin gene expression, but interplay with the (AT)(X)T(Y) sites in cis and in trans may occur. In contrast, while the XmnI sequence is clearly correlated with gamma-globin...
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