Article
A sensitized PiggyBac-based screen for regulators of border cell migration in Drosophila.
Genetics - 1 Jul 2007
Mathieu Juliette, Sung Hsin-Ho, Pugieux Céline, Soetaert Jan, Rorth Pernille
Abstract excerpt
Migration of border cells during Drosophila melanogaster oogenesis is a good model system for investigating the genetic requirements for cell migration in vivo. We present a sensitized loss-of-function screen used to identify new genes required in border cells for their migration. Chromosomes bearing FRTs on all four major autosomal arms were mutagenized by insertions of the transposable element PiggyBac,...
Topics
- Animals
- Cell Movement
- DNA Transposable Elements
- Drosophila Proteins
- Drosophila melanogaster
- Inhibitor of Apoptosis Proteins
- JNK Mitogen-Activated Protein Kinases
- Mutation
- Oogenesis
- Receptor Protein-Tyrosine Kinases
- Signal Transduction
- Transcription, Genetic