Article
Transforming growth factor-beta 1 in rheumatoid synovial membrane and cartilage/pannus junction.
Clinical and experimental immunology - 1 Dec 1991
Chu C Q, Field M, Abney E, Zheng R Q, Allard S, Feldmann M, Maini R N
Abstract excerpt
Transforming growth factor (TGF)-beta has been shown to promote tissue repair and have immunosuppressive actions, and has been proposed to have a role in rheumatoid arthritis (RA). Using immunohistochemical techniques with rabbit F(ab')2 antibodies raised against recombinant human TGF-beta 1, we...
Topics
- Antibodies, Monoclonal
- Arthritis, Rheumatoid
- Dendritic Cells
- Fibroblasts
- Fluorescent Antibody Technique
- Humans
- Joints
- Macrophages
- Mixed Connective Tissue Disease
- Osteoarthritis
- Phenotype
- Synovial Membrane
- T-Lymphocytes
- Transforming Growth Factor beta