Article
Transforming growth factor-beta 1 in rheumatoid synovial membrane and cartilage/pannus junction.
Clinical and experimental immunology - 1 Dec 1991
Chu C Q, Field M, Abney E, Zheng R Q, Allard S, Feldmann M, Maini R N
Abstract excerpt
Transforming growth factor (TGF)-beta has been shown to promote tissue repair and have immunosuppressive actions, and has been proposed to have a role in rheumatoid arthritis (RA). Using immunohistochemical techniques with rabbit F(ab')2 antibodies raised against recombinant human TGF-beta 1, we have detected TGF-beta 1 in the synovial tissue and cartilage/pannus junction (CPJ) from 18/18 patients with RA....
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