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Article

Apoptosis induced by depsipeptide FK228 coincides with inhibition of survival signaling in lung cancer cells.

Cancer journal (Sudbury, Mass.) - 1 Jan 2000

Yu Xiao-Dan, Wang Sheng-Yu, Chen G Aaron, Hou Chun-Mei, Zhao Ming, Hong Julie A, Nguyen Dao M, Schrump David S

Abstract excerpt

BACKGROUND: Whereas histone deacetylase inhibitors are known to modulate chromatin structure, the precise mechanisms by which these novel agents induce apoptosis in cancer cells remain unknown. Previously we reported that depsipeptide FK228 depletes epidermal growth factor receptor (EGFR), erbB2, and Raf-1 kinases in non-small cell lung cancer cells. In the present study we sought to further define the mechanisms...

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Source

Identifiers

PMID: 17476138
DOI: 10.1097/PPO.0b013e318046eedc

Genes

EGFR

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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