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Cytotoxic T lymphocyte-associated antigen-4 gene polymorphisms confer susceptibility to atopic asthma in Korean children.

Pediatric pulmonology - 1 Jun 2007

Sohn Myung Hyun, Kim Seung-Hyun, Song Tae-Won, Kim Kyung-Won, Kim Eun-Soo, Park Hae-Sim, Kim Kyu-Earn

Abstract excerpt

Cytotoxic T lymphocyte-associated antigen-4 (CTLA-4) is a negative regulator of T lymphocyte activation. The gene encoding CTLA-4 is a candidate gene for conferring susceptibility to allergic disease. The purpose of this study was to evaluate the potential effects of CTLA-4 gene polymorphisms in Korean children on asthma. We genotyped 272 children with atopic asthma, 54 children with nonatopic asthma (NAA), and...

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PMID: 17469155
DOI: 10.1002/ppul.20622

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