Article
Glucocerebrosidase mutations in Chinese subjects from Taiwan with sporadic Parkinson disease.
Molecular genetics and metabolism - 1 Jun 2007
Ziegler Shira G, Eblan Michael J, Gutti Usha, Hruska Kathleen S, Stubblefield Barbara K, Goker-Alpan Ozlem, LaMarca Mary E, Sidransky Ellen
Abstract excerpt
BACKGROUND: An association between glucocerebrosidase, the enzyme deficient in Gaucher disease, and the synucleinopathies has been suggested both by the development of parkinsonism in Gaucher probands and carriers, as well as by the presence of mutations in the gene for glucocerebrosidase (GBA) in different series of subjects with synucleinopathies. In this study, an open access Parkinson repository was used to...
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