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Article

Bestrophin gene mutations cause canine multifocal retinopathy: a novel animal model for best disease.

Investigative ophthalmology & visual science - 1 May 2007

Guziewicz Karina E, Zangerl Barbara, Lindauer Sarah J, Mullins Robert F, Sandmeyer Lynne S, Grahn Bruce H, Stone Edwin M, Acland Gregory M, Aguirre Gustavo D

Abstract excerpt

PURPOSE: Canine multifocal retinopathy (cmr) is an autosomal recessive disorder of multiple dog breeds. The disease shares a number of clinical and pathologic similarities with Best macular dystrophy (BMD), and cmr is proposed as a new large animal model for Best disease. METHODS: cmr was characterized by ophthalmoscopy and histopathology and compared with BMD-affected patients. BEST1 (alias VMD2), the bestrophin...

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Source

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Identifiers

PMID: 17460247
DOI: 10.1167/iovs.06-1374
PMCID: PMC1931491

Genes

RPE
BEST1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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