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Article

Prior chronic in vivo glucocorticoid excess leads to an anabolic phenotype and an extension of cellular life span of skin fibroblasts in vitro.

Annals of the New York Academy of Sciences - 1 Apr 2007

Kletsas Dimitris, Pratsinis Harris, Gioni Vassiliki, Pilichos Konstantinos, Yiacoumettis Andreas M, Tsagarakis Stylianos

Abstract excerpt

Intense stress can be detrimental for tissue homeostasis and accelerates aging. On the other hand, repeated mild stresses can have beneficial and even life-prolonging effects. Hypersecretion of glucocorticoids (GCs) represents the major hormonal response to stress. However, besides its life-susta...

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Identifiers

PMID: 17460210
DOI: 10.1196/annals.1395.050

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-17460210-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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