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Article

A putative new domain target for anti-hepatitis B virus: residues flanking hepatitis B virus reverse transcriptase residue 306 (rtP306).

Journal of medical virology - 1 Jun 2007

Wang Yong-Xiang, Xu Xiang, Luo Cheng, Ma Zhang-Mei, Jiang Hua-Liang, Ding Jian-Ping, Wen Yu-Mei

Abstract excerpt

Previous work showed that conservation of proline at residue 306 (rtP306) of hepatitis B virus (HBV) reverse transcriptase (RT) is crucial for virus replication and encapsidation of pregenomic RNA (pgRNA). In this study, the functions of residues flanking rtP306 in HBV RT (rtG304, rtY305, rtA307, rtL308 and rtL311) are presented. Alanine or phenylalanine was used to substitute these residues by constructing...

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PMID: 17457904
DOI: 10.1002/jmv.20835

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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