Article
Effect of the G-308A polymorphism of the tumor necrosis factor alpha gene on the risk of ischemic heart disease and ischemic stroke: a meta-analysis.
American heart journal - 1 May 2007
Pereira Tiago V, Rudnicki Martina, Franco Rendrik F, Pereira Alexandre C, Krieger José E
Abstract excerpt
BACKGROUND: Under the hypothesis that the G-308A polymorphism in the promoter region of the tumor necrosis factor alpha gene might increase tumor necrosis factor alpha expression, several investigations have been performed to examine the influence of the -308A allele on the risk of cardiovascular events. The results of these studies, however, have been conflicting. To provide a more robust estimate of the...
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