Article
Application of HapMap data to the evaluation of 8 candidate genes for pediatric slow transit constipation.
Journal of pediatric surgery - 1 Apr 2007
Garcia-Barcelo Mercè, King Sebastian K, Miao Xiaoping, So Man-ting, Holden William T, Moore Jason H, Sutcliffe Jonathan R, Hutson John M, Tam Paul K H
Abstract excerpt
BACKGROUND: Slow transit constipation (STC) affects up to 3% of all children and is an increasingly recognized cause of chronic constipation in children. We conducted a pilot study to investigate whether genes encoding neurotransmitters (TAC1, TAC3, VIP, NOS1) and receptors (TACR1, TACR2, TACR3, KIT) could be responsible for STC. METHODS: One hundred seventeen tag single nucleotide polymorphisms (SNPs),...
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