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The dynein light chain 8 binding motif of rabies virus phosphoprotein promotes efficient viral transcription

16 Apr 2007

Abstract excerpt

Recent studies indicate that the interaction between rabies virus (RV) phosphoprotein and the dynein light chain 8 (LC8) is essential for RV pathogenesis. Through its association with the dynein motor complex, LC8 has been suggested as a molecular factor that links the viral ribonucleoprotein to the host cell transport system. Recent structural investigations, however, dispute this model. To understand the role...

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PMID: 17438267
DOI: 10.1073/pnas.0701397104

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