Article
Steroid-responsive neurologic relapses in a child with a proteolipid protein-1 mutation.
Neurology - 17 Apr 2007
Gorman M P, Golomb M R, Walsh L E, Hobson G M, Garbern J Y, Kinkel R P, Darras B T, Urion D K, Eksioglu Y Z
Abstract excerpt
A 10-year-old boy developed corticosteroid-responsive relapsing neurologic signs, including nystagmus and ataxia. MRI revealed multifocal T2 white matter hyperintensities; several were gadolinium-enhancing. CSF contained oligoclonal bands. Although the patient met criteria for multiple sclerosis (MS), the proteolipid protein-1 gene (PLP1) contained a mutation in exon 3B (c.409C>T), predicting a...
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