Aggressive phenotype of multiple sclerosis, characterised by atypical initial symptoms and a fulminant clinical progression.

Abstract excerpt

A previously healthy male in his late 40s presented with progressively worsening neurological symptoms-tetraparesis, visual disturbances, aphasia and dysphagia. Brain MRI revealed multiple large contrast-enhancing lesions with mass effect. After extensive investigation, a demyelinating central nervous system (CNS) disease was suspected; however, a differential diagnosis with primary CNS vasculitis was also...

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